MolNFT v1 · #143428 · protein
Crystal structure of the bptf phd-bromodomain module bound to H3KC4ME3 methyl lysine analog
6AZE · Nucleosome-remodeling factor subunit bptf: “Crystal structure of the bptf phd-bromodomain module bound to H3KC4ME3 methyl lysine analog”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.53). MolNFT v1 #143428 on…
- PDB
- 6AZE
- Type
- protein
- Length
- 173 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleosome-remodeling factor subunit bptf; Ala-arg-thr-ML3-gln-thr
- UniProt
- Q12830
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleosome-remodeling factor subunit bptf | protein | 167 | 56% helix, 6% strand | Q12830 |
| P | Ala-arg-thr-ML3-gln-thr | protein | 6 | 0% helix, 33% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.53 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–P · 552 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
- 6AZE · Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12830
- Elsewhere: RCSB PDB 6AZE · PDBe 6AZE · UniProt Q12830
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