MolNFT v1 · #143366 · protein

Structure of RASGRP4 in complex with HRAS

6AXG · RAS guanyl-releasing protein 4: “Structure of RASGRP4 in complex with HRAS”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #143366 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AXG
Type: protein
Length: 2,936 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS guanyl-releasing protein 4; GTPase HRAS
UniProt: Q8TDF6, P01112
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 12 distinct chains · 61% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS guanyl-releasing protein 4	protein	338	69% helix, 1% strand	Q8TDF6
B	GTPase HRAS	protein	156	40% helix, 25% strand	P01112
C	RAS guanyl-releasing protein 4	protein	336	72% helix, 1% strand	Q8TDF6
D	GTPase HRAS	protein	158	39% helix, 26% strand	P01112
E	RAS guanyl-releasing protein 4	protein	330	72% helix, 0% strand	Q8TDF6
F	GTPase HRAS	protein	158	36% helix, 25% strand	P01112
G	RAS guanyl-releasing protein 4	protein	320	71% helix, 0% strand	Q8TDF6
H	GTPase HRAS	protein	157	39% helix, 23% strand	P01112
I	RAS guanyl-releasing protein 4	protein	334	71% helix, 0% strand	Q8TDF6
J	GTPase HRAS	protein	157	38% helix, 25% strand	P01112
K	RAS guanyl-releasing protein 4	protein	337	71% helix, 0% strand	Q8TDF6
L	GTPase HRAS	protein	155	39% helix, 25% strand	P01112

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.75	0.97	20	empty
2	403	0.75	0.84	48	empty
3	76	0.74	0.97	20	empty
4	68	0.73	0.97	21	empty
5	249	0.73	0.87	38	empty

Interfaces

13 interfaces between chains.

C–D · 1823 Å² buried · 31 hydrogen bonds · protein-protein
G–H · 1794 Å² buried · 33 hydrogen bonds · protein-protein
E–F · 1777 Å² buried · 18 hydrogen bonds · protein-protein
K–L · 1688 Å² buried · 26 hydrogen bonds · protein-protein
I–J · 1680 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

6AXG · Structure of RasGRP4 in complex with HRas · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TDF6
Every structure of UniProt P01112
Elsewhere: RCSB PDB 6AXG · PDBe 6AXG · UniProt Q8TDF6 · UniProt P01112

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.