MolNFT v1 · #143357 · protein
The crystal structure of a lysyl hydroxylase from acanthamoeba polyphaga mimivirus
6AX6 · Procollagen lysyl hydroxylase and glycosyltransferase: “The crystal structure of a lysyl hydroxylase from acanthamoeba polyphaga mimivirus”. X-ray diffraction, 2 ligands (FE2, IOD), 3 pockets (best druggability 0.65). MolNFT v1…
- PDB
- 6AX6
- Type
- protein
- Length
- 386 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Procollagen lysyl hydroxylase and glycosyltransferase
- EC
- 1.14.11.4
- UniProt
- Q5UQC3
- Ligands
- FE2, IOD
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Procollagen lysyl hydroxylase and glycosyltransferase (EC 1.14.11.4) | protein | 189 | 26% helix, 32% strand | Q5UQC3 |
| B | Procollagen lysyl hydroxylase and glycosyltransferase (EC 1.14.11.4) | protein | 197 | 27% helix, 32% strand | Q5UQC3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 200 | 0.65 | 0.84 | 35 | IOD, FE2 |
| 2 | 160 | 0.64 | 0.85 | 34 | IOD, FE2 |
| 3 | 60 | 0.41 | 0.81 | 13 | IOD |
Interfaces
1 interface between chains.
- A–B · 933 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6AX6 · The crystal structure of a lysyl hydroxylase from Acanthamoeba polyphaga mimivirus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5UQC3
- Elsewhere: RCSB PDB 6AX6 · PDBe 6AX6 · UniProt Q5UQC3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.