MolNFT v1 · #143321 · protein

Crystal structure of the hopq-CEACAM3 L44Q complex

6AW3: “Crystal structure of the hopq-CEACAM3 L44Q complex”. X-ray diffraction, 2 pockets (best druggability 0.57). MolNFT v1 #143321 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6AW3
Type: protein
Length: 459 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hopq; Carcinoembryonic antigen-related cell adhesion molecule 3
UniProt: H6A3H4, P40198
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Hopq	protein	351	51% helix, 15% strand	H6A3H4
A	Carcinoembryonic antigen-related cell adhesion molecule 3	protein	108	6% helix, 51% strand	P40198

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	170	0.57	0.81	32	empty
2	73	0.35	0.76	18	empty

Interfaces

1 interface between chains.

B–A · 1026 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6AW3 · Crystal structure of the HopQ-CEACAM3 L44Q complex · the same entry in another collection · chain B against B, TM-score 1.00
P40198 · AlphaFold monomer V2.0 prediction for carcinoembryonic antigen- related cell adhesion… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H6A3H4
Every structure of UniProt P40198
Elsewhere: RCSB PDB 6AW3 · PDBe 6AW3 · UniProt H6A3H4 · UniProt P40198

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.