Research workbench
Crystal structure of the hopq-CEACAM3 L44Q complex
Analyse Crystal structure of the hopq-CEACAM3 L44Q complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6AW3
- Type
- protein
- Length
- 459 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hopq; Carcinoembryonic antigen-related cell adhesion molecule 3
- UniProt
- H6A3H4, P40198
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Hopq | protein | 351 | 51% helix, 15% strand | H6A3H4 |
| A | Carcinoembryonic antigen-related cell adhesion molecule 3 | protein | 108 | 6% helix, 51% strand | P40198 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 170 | 0.57 | 0.81 | 32 | empty |
| 2 | 73 | 0.35 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- B–A · 1026 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6AW3 · Crystal structure of the HopQ-CEACAM3 L44Q complex · the same entry in another collection · chain B against B, TM-score 1.00
- P40198 · AlphaFold monomer V2.0 prediction for carcinoembryonic antigen- related cell adhesion… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H6A3H4
- Every structure of UniProt P40198
- Elsewhere: RCSB PDB 6AW3 · PDBe 6AW3 · UniProt H6A3H4 · UniProt P40198
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