MolNFT v1 · #143115 · protein

Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((guanine-9H-YL)METHYL)PROPANE-1,3 DIYL)BIS(OXY) ]BIS(METHYLENE))DIPHOSPHONIC acid

6APS: “Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with…”. X-ray diffraction, 3 ligands (SV2, MG, SO4). MolNFT v1 #143115 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6APS
Type: protein
Length: 364 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q07010
Ligands: SV2, MG, SO4

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	185	—	Q07010
B	—	protein	179	—	Q07010

Ligands and binding sites

SV2 · [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid) · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · chains A
PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6APS · Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Q07010 · AlphaFold monomer V2.0 prediction for hypoxanthine-guanine phosphoribosyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07010
Elsewhere: RCSB PDB 6APS · PDBe 6APS · UniProt Q07010

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.