UniProt Q07010
Hypoxanthine-guanine phosphoribosyltransferase (Q07010)
Hypoxanthine-guanine phosphoribosyltransferase (UniProt Q07010), EC 2.4.2.8: 24 experimental structures on GenesisL1, 15 ligands bound, 50 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q07010
- Protein
- Hypoxanthine-guanine phosphoribosyltransferase
- EC
- 2.4.2.8
- Experimental structures
- 24
- Predicted models
- 0
- Ligands
- 15
- Pockets
- 50 · 0 records with a druggable one
Structures
24 records of Q07010 in the MolNFT archive: 24 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5JSQ | Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a… | x-ray diffraction | A, B | 6MS, MG, SO4 | — |
| 5JSQ | Trypanosome brucei hypoxanthine-guanine phosphoribosyltranferase in complex with a… | x-ray diffraction | A, B | — | — |
| 5JV5 | Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with Guanosine 5'… | x-ray diffraction | A, B | 5GP, SO4, MG | 5 (best 0.43) |
| 5JV5 | Trypanosome brucei hypoxanthine-guanine phosphoribosyltranferase in complex with guanosine 5'… | x-ray diffraction | A, B | 5GP, SO4, MG | 5 (best 0.43) |
| 5K51 | Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a… | x-ray diffraction | A, B, C, D | 6QD | — |
| 5K51 | Trypanosome brucei hypoxanthine-guanine phosphoribosyltranferase in complex with a… | x-ray diffraction | A, B, C, D | 6QD | — |
| 5KAM | Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with Inosine 5'… | x-ray diffraction | A, C | IMP, SO4, MG | 2 (best 0.43) |
| 5KAM | Trypanosome brucei hypoxanthine-guanine phosphoribosyltranferase in complex with inosine 5'… | x-ray diffraction | A, C | IMP, SO4, MG | — |
| 5KAP | Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a… | x-ray diffraction | A, B | 6RH, SO4, MG | 2 (best 0.45) |
| 5KAP | Trypanosome brucei hypoxanthine-guanine phosphoribosyltranferase in complex with a… | x-ray diffraction | A, B | 6RH, SO4, MG | — |
| 6APS | Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | SV2, MG, SO4 | 6 (best 0.38) |
| 6APS | Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | SV2, MG, SO4 | — |
| 6APT | Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | 45T | — |
| 6APU | Crystal structure of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex… | x-ray diffraction | A, B | SO4, MG, 3L6 | 5 (best 0.46) |
| 6APU | Crystal structure of trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex… | x-ray diffraction | A, B | SO4, MG, 3L6 | — |
| 6APV | Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | 3L4, MG | 8 (best 0.48) |
| 6APV | Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B, C, D | 3L4, MG | — |
| 6MXG | Crystal structure of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex… | x-ray diffraction | A, B | XMP, MG, SO4 | — |
| 6MXG | Crystal structure of trypanosoma brucei hypoxanthine-guanine phosphoribosyltranferase in complex… | x-ray diffraction | A, B | XMP, MG, SO4 | — |
| 7SB7 | Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | 8QI | — |
| 7SB7 | Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | 8QI | — |
| 8TR1 | Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex… | x-ray diffraction | A, B, C, D | JEI | 11 (best 0.44) |
| 8TS4 | Crystal structure of T. Brucei hypoxanthine guanine phosphoribosyltransferase in complex with… | x-ray diffraction | A, B | MG, KFF | 6 (best 0.39) |
| Q07010 | AlphaFold monomer V2.0 prediction for hypoxanthine-guanine phosphoribosyltransferase (Q07010) | — | — | — |
Ligands
- MG · Magnesium ion · in 16 records
- SO4 · Sulfate ion · in 13 records
- 3L4 · [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) ethyl][(e)-2-phosphonoethenyl]amino}ethoxy) methyl]phosphonic acid · in 2 records
- 3L6 · (2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) ethyl](3-aminopropyl)amino}ethyl)phosphonic acid · in 2 records
- 5GP · Guanosine-5'-monophosphate · in 2 records
- 6QD · 5-(6-oxidanylidene-3~{H}-purin-9-yl)pentylphosphonic acid · in 2 records
- 6RH · 4-(6-oxidanylidene-1~{H}-purin-9-yl)butylphosphonic acid · in 2 records
- 8QI · ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl) phosphonic acid · in 2 records
- IMP · Inosinic acid · in 2 records
- SV2 · [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid) · in 2 records
- XMP · Xanthosine-5'-monophosphate · in 2 records
- 45T · {[(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) propane-1,2-diyl]bis(oxyethane-2,1-diyl) }bis(phosphonic acid) · in 1 record
- 6MS · [6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)hexyl]phosphonic acid · in 1 record
- JEI · (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid · in 1 record
- KFF · (3-{(2S,4S)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid · in 1 record
Elsewhere
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