MolNFT v1 · #14279 · protein

Crystal structure of human interleukin-2

1M4C: “Crystal structure of human interleukin-2”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #14279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1M4C
Type: protein
Length: 229 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-2
UniProt: P60568
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-2	protein	114	68% helix, 4% strand	P60568
B	Interleukin-2	protein	115	68% helix, 3% strand	P60568

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.40	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 335 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1M4C · Crystal Structure of Human Interleukin-2 · the same entry in another collection · chain A against A, TM-score 1.00
P60568 · AlphaFold monomer V2.0 prediction for interleukin-2 (P60568) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60568
Elsewhere: RCSB PDB 1M4C · PDBe 1M4C · UniProt P60568

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