MolNFT v1 · #14278 · protein
Crystal structure of human interleukin-2 K43C covalently modified at C43 with 2-[2-(2-cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N- (3-mercapto-propyl)-propionamide
1M4B: “Crystal structure of human interleukin-2 K43C covalently modified at C43 with…”. X-ray diffraction, 1 ligand (NMP). MolNFT v1 #14278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1M4B
- Type
- protein
- Length
- 116 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-2
- UniProt
- P60568
- Ligands
- NMP
Structure
x-ray diffraction · 1 distinct chain · 66% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-2 | protein | 116 | 66% helix, 3% strand | P60568 |
Ligands and binding sites
- NMP · 2-[2-(2-cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 1 covalent, 1 disulfide (covalent ligand, disulfide).
Compared structures
- 1M4B · Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with… · the same entry in another collection · chain A against A, TM-score 1.00
- P60568 · AlphaFold monomer V2.0 prediction for interleukin-2 (P60568) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60568
- Elsewhere: RCSB PDB 1M4B · PDBe 1M4B · UniProt P60568
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