MolNFT v1 · #14272 · protein

Crystal structure of MLC1P bound to IQ2 of MYO2P, a class V myosin

1M45 · Myosin light chain: “Crystal structure of MLC1P bound to IQ2 of MYO2P, a class V myosin”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #14272 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1M45
Type: protein
Length: 167 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin light chain; IQ2 motif from MYO2P, a class V myosin
UniProt: P53141, P19524
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 59% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin light chain	protein	142	54% helix, 8% strand	P53141
B	IQ2 motif from MYO2P, a class V myosin	protein	25	92% helix, 0% strand	P19524

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.33	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 1371 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1M45 · Crystal structure of MLC1P bound to IQ2 of MYO2P, a class V myosin · the same entry in another collection · chain A against A, TM-score 1.00
P53141 · AlphaFold monomer V2.0 prediction for myosin light chain 1 (P53141) · a predicted model of the same protein · chain A against A, TM-score 0.84
P19524 · AlphaFold monomer V2.0 prediction for myosin-2 (P19524) · a predicted model of the same protein · chain B against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53141
Every structure of UniProt P19524
Elsewhere: RCSB PDB 1M45 · PDBe 1M45 · UniProt P53141 · UniProt P19524

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