MolNFT v1 · #142526 · protein
The crystal structure of the mtb maze-mazf-MT9 complex
6A6X · Probable endoribonuclease MAZF7: “The crystal structure of the mtb maze-mazf-MT9 complex”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.54). MolNFT v1 #142526 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6A6X
- Type
- protein
- Length
- 351 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable endoribonuclease MAZF7; Antitoxin MAZE7
- EC
- 3.1.-.-
- UniProt
- P0CL62, P9WJ85
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 43% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable endoribonuclease MAZF7 (EC 3.1.-.-) | protein | 112 | 23% helix, 34% strand | P0CL62 |
| B | Probable endoribonuclease MAZF7 (EC 3.1.-.-) | protein | 110 | 24% helix, 35% strand | P0CL62 |
| C | Antitoxin MAZE7 | protein | 75 | 77% helix, 9% strand | P9WJ85 |
| D | Antitoxin MAZE7 | protein | 54 | 76% helix, 13% strand | P9WJ85 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.54 | 0.83 | 28 | empty |
| 2 | 104 | 0.44 | 0.78 | 30 | SO4 |
Interfaces
4 interfaces between chains.
- C–D · 1590 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 1054 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 1052 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 614 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6A6X · The crystal structure of the Mtb MazE-MazF-mt9 complex · the same entry in another collection · chain D against D, TM-score 1.00
- P0CL62 · AlphaFold monomer V2.0 prediction for probable endoribonuclease MAZF7 (P0CL62) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P9WJ85 · AlphaFold monomer V2.0 prediction for antitoxin MAZE7 (P9WJ85) · a predicted model of the same protein · chain D against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0CL62
- Every structure of UniProt P9WJ85
- Elsewhere: RCSB PDB 6A6X · PDBe 6A6X · UniProt P0CL62 · UniProt P9WJ85
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