MolNFT v1 · #142474 · protein

The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin

6A5F · Ngnd: “The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #142474 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6A5F
Type: protein
Length: 302 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ngnd
Pockets: 2 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ngnd	protein	151	28% helix, 39% strand	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.67	0.86	34	empty
2	184	0.65	0.84	31	empty

Interfaces

1 interface between chains.

A–B · 711 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6A5F · The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6A5F · PDBe 6A5F

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