Research workbench
The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin
Analyse The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6A5F
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ngnd
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ngnd | protein | 151 | 28% helix, 39% strand | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.67 | 0.86 | 34 | empty |
| 2 | 184 | 0.65 | 0.84 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 711 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6A5F · The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6A5F · PDBe 6A5F
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