MolNFT v1 · #142156 · protein

Fgfr-1 in complex with ligand lenvatinib

5ZV2: “Fgfr-1 in complex with ligand lenvatinib”. X-ray diffraction, 1 ligand (LEV). MolNFT v1 #142156 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ZV2
Type: protein
Length: 566 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P11362
Ligands: LEV

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	284	—	P11362
B	—	protein	282	—	P11362

Ligands and binding sites

LEV · 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5ZV2 · FGFR-1 in complex with ligand lenvatinib · the same entry in another collection · chain A against A, TM-score 1.00
P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11362
Elsewhere: RCSB PDB 5ZV2 · PDBe 5ZV2 · UniProt P11362

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