MolNFT v1 · #142102 · protein

Sirb from bacillus subtilis with CO2+

5ZT7 · Sirohydrochlorin ferrochelatase: “Sirb from bacillus subtilis with CO2+”. X-ray diffraction, 1 ligand (CO), 6 pockets (best druggability 0.71). MolNFT v1 #142102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ZT7
Type: protein
Length: 506 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sirohydrochlorin ferrochelatase
EC: 4.99.1.4
UniProt: O34632
Ligands: CO
Pockets: 6 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sirohydrochlorin ferrochelatase (EC 4.99.1.4)	protein	254	42% helix, 19% strand	O34632
B	Sirohydrochlorin ferrochelatase (EC 4.99.1.4)	protein	252	42% helix, 18% strand	O34632

Ligands and binding sites

CO · Cobalt (II) ion · metal · 9 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	337	0.71	0.83	30	empty
2	388	0.66	0.79	40	empty
3	260	0.53	0.76	40	empty
4	131	0.49	0.79	19	empty
5	82	0.36	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 557 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5ZT7 · SirB from Bacillus subtilis with Co2+ · the same entry in another collection · chain A against A, TM-score 1.00
O34632 · AlphaFold monomer V2.0 prediction for sirohydrochlorin ferrochelatase (O34632) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O34632
Elsewhere: RCSB PDB 5ZT7 · PDBe 5ZT7 · UniProt O34632

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