MolNFT v1 · #142034 · protein
Structure of human mitochondrial trifunctional protein, tetramer
5ZQZ · Trifunctional enzyme subunit alpha, mitochondrial: “Structure of human mitochondrial trifunctional protein, tetramer”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #142034 on GenesisL1: 3D structure, binding…
- PDB
- 5ZQZ
- Type
- protein
- Length
- 2,262 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trifunctional enzyme subunit alpha, mitochondrial; Trifunctional enzyme subunit beta…
- EC
- 4.2.1.17, 1.1.1.211, 2.3.1.16
- UniProt
- P40939, P55084
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 35% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Trifunctional enzyme subunit alpha, mitochondrial (EC 4.2.1.17, 1.1.1.211) | protein | 711 | 40% helix, 9% strand | P40939 |
| B, D | Trifunctional enzyme subunit beta, mitochondrial (EC 2.3.1.16) | protein | 420 | 26% helix, 14% strand | P55084 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 874 | 0.83 | 0.85 | 106 | empty |
| 2 | 751 | 0.83 | 0.86 | 91 | empty |
| 3 | 893 | 0.81 | 0.83 | 120 | empty |
| 4 | 584 | 0.80 | 0.85 | 83 | empty |
| 5 | 160 | 0.77 | 0.94 | 43 | empty |
Interfaces
5 interfaces between chains.
- B–D · 2954 Ų buried · 32 hydrogen bonds · protein-protein
- C–D · 918 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 907 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 622 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 622 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5ZQZ · Structure of human mitochondrial trifunctional protein, tetramer · the same entry in another collection · chain D against D, TM-score 1.00
- P55084 · AlphaFold monomer V2.0 prediction for trifunctional enzyme subunit beta, mitochondrial… · a predicted model of the same protein · chain B against A, TM-score 0.97
- P40939 · AlphaFold monomer V2.0 prediction for trifunctional enzyme subunit alpha, mitochondrial… · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40939
- Every structure of UniProt P55084
- Elsewhere: RCSB PDB 5ZQZ · PDBe 5ZQZ · UniProt P40939 · UniProt P55084
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