MolNFT v1 · #142022 · protein
Crystal structure of human katanin aaa ATPase domain complex with atpgammas
5ZQM · Katanin P60 ATPase-containing subunit A1: “Crystal structure of human katanin aaa ATPase domain complex with atpgammas”. X-ray diffraction, 1 ligand (AGS), 2 pockets (best druggability 0.44). MolNFT v1 #142022 on GenesisL1: 3D…
- PDB
- 5ZQM
- Type
- protein
- Length
- 290 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Katanin P60 ATPase-containing subunit A1
- EC
- 3.6.4.3
- UniProt
- O75449
- Ligands
- AGS
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Katanin P60 ATPase-containing subunit A1 (EC 3.6.4.3) | protein | 290 | 50% helix, 10% strand | O75449 |
Ligands and binding sites
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.44 | 0.77 | 30 | AGS |
| 2 | 88 | 0.41 | 0.78 | 22 | empty |
Compared structures
- 5ZQM · Crystal structure of human katanin AAA ATPase domain complex with ATPgammaS · the same entry in another collection · chain A against A, TM-score 1.00
- O75449 · AlphaFold monomer V2.0 prediction for katanin P60 ATPase-containing subunit A1 (O75449) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75449
- Elsewhere: RCSB PDB 5ZQM · PDBe 5ZQM · UniProt O75449
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