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Crystal structure of human katanin aaa ATPase domain complex with atpgammas

Analyse Crystal structure of human katanin aaa ATPase domain complex with atpgammas in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5ZQM
Type: protein
Length: 290 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Katanin P60 ATPase-containing subunit A1
EC: 3.6.4.3
UniProt: O75449
Ligands: AGS
Pockets: 2 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Katanin P60 ATPase-containing subunit A1 (EC 3.6.4.3)	protein	290	50% helix, 10% strand	O75449

Ligands and binding sites

AGS · Phosphothiophosphoric acid-adenylate ester · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.44	0.77	30	AGS
2	88	0.41	0.78	22	empty

Compared structures

5ZQM · Crystal structure of human katanin AAA ATPase domain complex with ATPgammaS · the same entry in another collection · chain A against A, TM-score 1.00
O75449 · AlphaFold monomer V2.0 prediction for katanin P60 ATPase-containing subunit A1 (O75449) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75449
Elsewhere: RCSB PDB 5ZQM · PDBe 5ZQM · UniProt O75449

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