MolNFT v1 · #14191 · protein

Beta-catenin armadillo repeat domain bound to icat

1M1E: “Beta-catenin armadillo repeat domain bound to icat”. X-ray diffraction, 2 pockets (best druggability 0.65). MolNFT v1 #14191 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1M1E
Type: protein
Length: 577 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-catenin; Icat
UniProt: Q02248, Q9NSA3
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-catenin	protein	512	74% helix, 1% strand	Q02248
B	Icat	protein	65	54% helix, 0% strand	Q9NSA3

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	478	0.65	0.78	49	empty
2	51	0.35	0.79	16	empty

Interfaces

1 interface between chains.

A–B · 1579 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

1M1E · Beta-catenin armadillo repeat domain bound to ICAT · the same entry in another collection · chain A against A, TM-score 1.00
Q02248 · AlphaFold monomer V2.0 prediction for catenin beta-1 (Q02248) · a predicted model of the same protein · chain A against A, TM-score 0.98
Q9NSA3 · AlphaFold monomer V2.0 prediction for beta-catenin-interacting protein 1 (Q9NSA3) · a predicted model of the same protein · chain B against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02248
Every structure of UniProt Q9NSA3
Elsewhere: RCSB PDB 1M1E · PDBe 1M1E · UniProt Q02248 · UniProt Q9NSA3

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