Research workbench
Beta-catenin armadillo repeat domain bound to icat
Analyse Beta-catenin armadillo repeat domain bound to icat in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M1E
- Type
- protein
- Length
- 577 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-catenin; Icat
- UniProt
- Q02248, Q9NSA3
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-catenin | protein | 512 | 74% helix, 1% strand | Q02248 |
| B | Icat | protein | 65 | 54% helix, 0% strand | Q9NSA3 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 478 | 0.65 | 0.78 | 49 | empty |
| 2 | 51 | 0.35 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1579 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 1M1E · Beta-catenin armadillo repeat domain bound to ICAT · the same entry in another collection · chain A against A, TM-score 1.00
- Q02248 · AlphaFold monomer V2.0 prediction for catenin beta-1 (Q02248) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NSA3 · AlphaFold monomer V2.0 prediction for beta-catenin-interacting protein 1 (Q9NSA3) · a predicted model of the same protein · chain B against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02248
- Every structure of UniProt Q9NSA3
- Elsewhere: RCSB PDB 1M1E · PDBe 1M1E · UniProt Q02248 · UniProt Q9NSA3
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