MolNFT v1 · #141907 · protein

X-ray structure of protein kinase CK2 alpha subunit H148S mutant

5ZN3 · Casein kinase II subunit alpha: “X-ray structure of protein kinase CK2 alpha subunit H148S mutant”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.66). MolNFT v1 #141907 on GenesisL1: 3D structure, binding sites…

PDB: 5ZN3
Type: protein
Length: 324 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase II subunit alpha
EC: 2.7.11.1
UniProt: P68400
Ligands: SO4
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase II subunit alpha (EC 2.7.11.1)	protein	324	40% helix, 15% strand	P68400

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	413	0.66	0.79	42	empty
2	61	0.61	0.92	26	empty
3	54	0.29	0.75	14	SO4

Compared structures

5ZN3 · X-ray structure of protein kinase ck2 alpha subunit H148S mutant · the same entry in another collection · chain A against A, TM-score 1.00
P68400 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P68400) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68400
Elsewhere: RCSB PDB 5ZN3 · PDBe 5ZN3 · UniProt P68400

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