MolNFT v1 · #141891 · protein
Stapled-peptides tailored against initiation of translation
5ZML · Eukaryotic translation initiation factor 4E: “Stapled-peptides tailored against initiation of translation”. X-ray diffraction, 2 ligands (ACE, NO3), 1 pocket (best druggability 0.45). MolNFT v1 #141891 on GenesisL1: 3D structure…
- PDB
- 5ZML
- Type
- protein
- Length
- 205 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; ACE-lys-lys-arg-tyr-ser-arg-MK8-gln-leu-leu-M…
- UniProt
- P06730
- Ligands
- ACE, NO3
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 191 | 34% helix, 27% strand | P06730 |
| B | ACE-lys-lys-arg-tyr-ser-arg-MK8-gln-leu-leu-MK8-phe-arg- arg | protein | 14 | 43% helix, 0% strand | — |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains B
- NO3 · Nitrate ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.45 | 0.76 | 18 | EDO |
Interfaces
1 interface between chains.
- A–B · 689 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified, 1 covalent (nonstandard, covalent ligand).
Compared structures
- 5ZML · Stapled-peptides tailored against initiation of translation · the same entry in another collection · chain A against A, TM-score 1.00
- P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06730
- Elsewhere: RCSB PDB 5ZML · PDBe 5ZML · UniProt P06730
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