MolNFT v1 · #141880 · protein

Crystal structure of ORP1-ord in complex with cholesterol at 3.4 a resolution

5ZM7 · Oxysterol-binding protein-related protein 1: “Crystal structure of ORP1-ord in complex with cholesterol at 3.4 a resolution”. X-ray diffraction, 1 ligand (CLR), 2 pockets (best druggability 0.77). MolNFT v1 #141880 on GenesisL1: 3D…

PDB: 5ZM7
Type: protein
Length: 366 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Oxysterol-binding protein-related protein 1
UniProt: Q9BXW6
Ligands: CLR
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 23% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Oxysterol-binding protein-related protein 1	protein	366	23% helix, 33% strand	Q9BXW6

Ligands and binding sites

CLR · Cholesterol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	507	0.77	0.84	55	CLR
2	68	0.45	0.82	12	empty

Compared structures

5ZM7 · Crystal structure of ORP1-ORD in complex with cholesterol at 3.4 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q9BXW6 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein- related protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BXW6
Elsewhere: RCSB PDB 5ZM7 · PDBe 5ZM7 · UniProt Q9BXW6

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