MolNFT v1 · #14177 · protein
Crystal structure of the complex of glycoprotein ib alpha and the von willebrand factor A1 domain
1M10: “Crystal structure of the complex of glycoprotein ib alpha and the von willebrand factor A1 domain”. X-ray diffraction, 3 pockets (best druggability 0.79). MolNFT v1 #14177 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1M10
- Type
- protein
- Length
- 466 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Von willebrand factor; Glycoprotein ib alpha
- UniProt
- P04275, P07359
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Von willebrand factor | protein | 199 | 38% helix, 22% strand | P04275 |
| B | Glycoprotein ib alpha | protein | 267 | 8% helix, 20% strand | P07359 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1049 | 0.79 | 0.81 | 77 | empty |
| 2 | 261 | 0.55 | 0.77 | 41 | empty |
| 3 | 73 | 0.40 | 0.79 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1155 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1M10 · Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor… · the same entry in another collection · chain A against A, TM-score 1.00
- P07359 · AlphaFold monomer V2.0 prediction for platelet glycoprotein ib alpha chain (P07359) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04275
- Every structure of UniProt P07359
- Elsewhere: RCSB PDB 1M10 · PDBe 1M10 · UniProt P04275 · UniProt P07359
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