Research workbench
Crystal structure of the complex of glycoprotein ib alpha and the von willebrand factor A1 domain
Analyse Crystal structure of the complex of glycoprotein ib alpha and the von… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M10
- Type
- protein
- Length
- 466 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Von willebrand factor; Glycoprotein ib alpha
- UniProt
- P04275, P07359
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Von willebrand factor | protein | 199 | 38% helix, 22% strand | P04275 |
| B | Glycoprotein ib alpha | protein | 267 | 8% helix, 20% strand | P07359 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1049 | 0.79 | 0.81 | 77 | empty |
| 2 | 261 | 0.55 | 0.77 | 41 | empty |
| 3 | 73 | 0.40 | 0.79 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1155 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1M10 · Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor… · the same entry in another collection · chain A against A, TM-score 1.00
- P07359 · AlphaFold monomer V2.0 prediction for platelet glycoprotein ib alpha chain (P07359) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04275
- Every structure of UniProt P07359
- Elsewhere: RCSB PDB 1M10 · PDBe 1M10 · UniProt P04275 · UniProt P07359
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