MolNFT v1 · #141591 · protein
Crystal structure of complex
5ZCJ · Tudor-interacting repair regulator protein: “Crystal structure of complex”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #141591 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZCJ
- Type
- protein
- Length
- 522 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tudor-interacting repair regulator protein; TP53-binding protein 1
- UniProt
- Q9BRJ7, Q12888
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 29% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tudor-interacting repair regulator protein | protein | 199 | 33% helix, 32% strand | Q9BRJ7 |
| B | Tudor-interacting repair regulator protein | protein | 202 | 34% helix, 31% strand | Q9BRJ7 |
| C | TP53-binding protein 1 | protein | 121 | 12% helix, 52% strand | Q12888 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1056 | 0.78 | 0.80 | 92 | empty |
| 2 | 54 | 0.70 | 0.98 | 17 | empty |
| 3 | 285 | 0.56 | 0.76 | 38 | empty |
| 4 | 73 | 0.43 | 0.80 | 14 | empty |
| 5 | 99 | 0.39 | 0.76 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1648 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 716 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 67 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5ZCJ · Crystal structure of complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BRJ7 · AlphaFold monomer V2.0 prediction for tudor-interacting repair regulator protein (Q9BRJ7) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q12888 · AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BRJ7
- Every structure of UniProt Q12888
- Elsewhere: RCSB PDB 5ZCJ · PDBe 5ZCJ · UniProt Q9BRJ7 · UniProt Q12888
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