MolNFT v1 · #141587 · protein
Crystal structure of alpha-glucosidase in complex with maltotetraose
5ZCE: “Crystal structure of alpha-glucosidase in complex with maltotetraose”. X-ray diffraction, 2 ligands (GLC, CA), 3 pockets (best druggability 0.69). MolNFT v1 #141587 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZCE
- Type
- protein
- Length
- 545 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-glucosidase
- Ligands
- GLC, CA
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-glucosidase | protein | 545 | 35% helix, 19% strand | — |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A
- CA · Calcium ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 481 | 0.69 | 0.79 | 44 | GLC |
| 2 | 86 | 0.37 | 0.77 | 20 | empty |
| 3 | 75 | 0.31 | 0.74 | 14 | empty |
Compared structures
- 5ZCE · Crystal structure of Alpha-glucosidase in complex with maltotetraose · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5ZCE · PDBe 5ZCE
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