MolNFT v1 · #141585 · protein
Crystal structure of alpha-glucosidase in complex with maltose
5ZCC: “Crystal structure of alpha-glucosidase in complex with maltose”. X-ray diffraction, 2 ligands (GLC, CA), 3 pockets (best druggability 0.69). MolNFT v1 #141585 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZCC
- Type
- protein
- Length
- 545 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-glucosidase
- Ligands
- GLC, CA
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-glucosidase | protein | 545 | 34% helix, 19% strand | — |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- CA · Calcium ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 501 | 0.69 | 0.79 | 43 | GLC |
| 2 | 124 | 0.46 | 0.78 | 28 | empty |
| 3 | 109 | 0.37 | 0.74 | 24 | empty |
Compared structures
- 5ZCC · Crystal structure of Alpha-glucosidase in complex with maltose · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5ZCC · PDBe 5ZCC
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