MolNFT v1 · #141478 · protein

Flavin-containing monooxygenase

5Z8T · Acyl-CoA dehydrogenase type 2 domain protein: “Flavin-containing monooxygenase”. X-ray diffraction, 1 ligand (FAD), 11 pockets (best druggability 0.81). MolNFT v1 #141478 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5Z8T
Type: protein
Length: 1,185 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acyl-CoA dehydrogenase type 2 domain protein
UniProt: C8WV06
Ligands: FAD
Pockets: 11 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Acyl-CoA dehydrogenase type 2 domain protein	protein	395	59% helix, 14% strand	C8WV06

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1128	0.81	0.82	97	FAD
2	1146	0.81	0.82	95	FAD
3	764	0.74	0.79	67	FAD
4	85	0.55	0.86	16	empty
5	136	0.53	0.81	21	empty

Interfaces

2 interfaces between chains.

B–C · 1684 Å² buried · 31 hydrogen bonds · protein-protein
A–B · 667 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

5Z8T · Flavin-containing monooxygenase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C8WV06
Elsewhere: RCSB PDB 5Z8T · PDBe 5Z8T · UniProt C8WV06

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