MolNFT v1 · #141454 · protein
Trimeric structure of vibrio cholerae heat shock protein 15 at 2.3 ångström resolution
5Z81: “Trimeric structure of vibrio cholerae heat shock protein 15 at 2.3 ångström resolution”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.69). MolNFT v1 #141454 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5Z81
- Type
- protein
- Length
- 297 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein 15
- UniProt
- A0A0H3AM46
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Heat shock protein 15 | protein | 99 | 35% helix, 21% strand | A0A0H3AM46 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B, C
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · 3 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 516 | 0.69 | 0.79 | 77 | empty |
| 2 | 268 | 0.55 | 0.76 | 20 | empty |
| 3 | 51 | 0.29 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 536 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 524 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 495 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5Z81 · Trimeric structure of Vibrio cholerae Heat Shock Protein 15 at 2.3 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H3AM46
- Elsewhere: RCSB PDB 5Z81 · PDBe 5Z81 · UniProt A0A0H3AM46
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