GL1X · GenesisL1 explorer

MolNFT v1 · #141422 · protein + DNA

Crystal structure of human DUX4 homeodomains bound to DNA

5Z6Z · Double homeobox protein 4: “Crystal structure of human DUX4 homeodomains bound to DNA”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #141422 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
5Z6Z
Type
protein + DNA
Length
160 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Double homeobox protein 4; DNA (5'- D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*AP*TP*CP*AP*CP*AP*…
UniProt
Q9UBX2
Pockets
3 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 69% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADouble homeobox protein 4protein12269% helix, 0% strandQ9UBX2
DDNA (5'- D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*AP*TP*CP*AP*CP*AP*CP*C)-3')dna19——
EDNA (5'- D(*GP*GP*TP*GP*TP*GP*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3')dna19——

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1640.710.9718empty
21180.430.7714empty
31080.370.7514empty

Interfaces

3 interfaces between chains.

  • A–E · 1159 Ų buried · 25 hydrogen bonds · protein-nucleic
  • A–D · 935 Ų buried · 25 hydrogen bonds · protein-nucleic
  • D–E · 837 Ų buried · 73 hydrogen bonds · nucleic-nucleic

Compared structures

  • 5Z6Z · Crystal structure of human DUX4 homeodomains bound to DNA · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9UBX2 · AlphaFold monomer V2.0 prediction for double homeobox protein 4 (Q9UBX2) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.