UniProt Q9UBX2
Double homeobox protein 4 (Q9UBX2)
Double homeobox protein 4 (UniProt Q9UBX2): 15 experimental structures and 1 predicted model on GenesisL1, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UBX2
- Protein
- Double homeobox protein 4
- Experimental structures
- 15
- Predicted models
- 1
- Pockets
- 19 · 4 records with a druggable one
Structures
16 records of Q9UBX2 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5Z2S | Crystal structure of DUX4-HD2 domain | x-ray diffraction | A | — | — |
| 5Z2S | Crystal structure of DUX4-HD2 domain | x-ray diffraction | A | — | — |
| 5Z2T | Crystal structure of DNA-bound DUX4-HD2 | x-ray diffraction | C, D | — | 2 (best 0.51) |
| 5Z2T | Crystal structure of DNA-bound DUX4-HD2 | x-ray diffraction | C, D | — | — |
| 5Z6Z | Crystal structure of human DUX4 homeodomains bound to DNA | x-ray diffraction | A | — | 3 (best 0.71) |
| 5Z6Z | Crystal structure of human DUX4 homeodomains bound to DNA | x-ray diffraction | A | — | — |
| 6A8R | Crystal structure of DUX4 HD2 domain associated with ERG DNA binding site | x-ray diffraction | B, A | — | 2 (best 0.29) |
| 6A8R | Crystal structure of DUX4 HD2 domain associated with erg DNA binding site | x-ray diffraction | B, A | — | — |
| 6DFY | Remodeled crystal structure of DNA-bound DUX4-HD2 | x-ray diffraction | C, D | — | 2 (best 0.44) |
| 6DFY | Remodeled crystal structure of DNA-bound DUX4-HD2 | x-ray diffraction | C, D | — | — |
| 6E8C | Crystal structure of the double homeodomain of DUX4 in complex with DNA | x-ray diffraction | A | — | — |
| 6U81 | Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer | x-ray diffraction | A | — | 5 (best 0.70) |
| 6U81 | Crystal structure of the double homeodomain of DUX4 in complex with a DNA aptamer | x-ray diffraction | A | — | — |
| 6U82 | Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer containing bulge… | x-ray diffraction | A, D | — | 5 (best 0.72) |
| 6U82 | Crystal structure of the double homeodomain of DUX4 in complex with a DNA aptamer containing bulge… | x-ray diffraction | A, D | — | — |
| Q9UBX2 | AlphaFold monomer V2.0 prediction for double homeobox protein 4 (Q9UBX2) | predicted | A | — | — |
Experiment against prediction
- 6U81 chain A against the predicted model Q9UBX2: TM-score 0.99, RMSD 0.44 Å
- 6U81 chain A against the predicted model Q9UBX2: TM-score 0.99, RMSD 0.44 Å
- 5Z6Z chain A against the predicted model Q9UBX2: TM-score 0.99, RMSD 0.44 Å
- 5Z6Z chain A against the predicted model Q9UBX2: TM-score 0.99, RMSD 0.44 Å
- 6U82 chain A against the predicted model Q9UBX2: TM-score 0.98, RMSD 0.63 Å
- 6U82 chain A against the predicted model Q9UBX2: TM-score 0.98, RMSD 0.63 Å
- 6E8C chain A against the predicted model Q9UBX2: TM-score 0.98, RMSD 0.83 Å
- 6U82 chain D against the predicted model Q9UBX2: TM-score 0.97, RMSD 0.99 Å
- 6U82 chain D against the predicted model Q9UBX2: TM-score 0.97, RMSD 0.99 Å
- 6DFY chain D against the predicted model Q9UBX2: TM-score 0.95, RMSD 0.66 Å
Elsewhere
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