MolNFT v1 · #141100 · protein
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and atpgammas (focused refinement on SUR1 ABC transporter module at 4.4A)
5YW7 · ATP-binding cassette sub-family C member 8 isoform X2: “Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and atpgammas (focused…”. Electron microscopy, 2 ligands (GBM, AGS), 20 pockets (best…
- PDB
- 5YW7
- Type
- protein
- Length
- 1,140 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-binding cassette sub-family C member 8 isoform X2
- UniProt
- A0A1U7R319
- Ligands
- GBM, AGS
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 64% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | ATP-binding cassette sub-family C member 8 isoform X2 | protein | 1140 | 64% helix, 8% strand | A0A1U7R319 |
Ligands and binding sites
- GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · ligand · chains B
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1173 | 0.82 | 0.83 | 114 | GBM |
| 2 | 58 | 0.71 | 0.97 | 18 | empty |
| 3 | 94 | 0.60 | 0.87 | 25 | empty |
| 4 | 135 | 0.56 | 0.82 | 24 | empty |
| 5 | 172 | 0.52 | 0.78 | 30 | empty |
Compared structures
- 5YW7 · Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1U7R319
- Elsewhere: RCSB PDB 5YW7 · PDBe 5YW7 · UniProt A0A1U7R319
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