MolNFT v1 · #141089 · protein

Crystal structure of full length NS3 protein (GD4NS2BNS3) from DENV4 in closed conformation

5YVV · Genome polyprotein: “Crystal structure of full length NS3 protein (GD4NS2BNS3) from DENV4 in closed conformation”. X-ray diffraction, 7 pockets (best druggability 0.81). MolNFT v1 #141089 on GenesisL1: 3D structure, binding sites…

PDB: 5YVV
Type: protein
Length: 630 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: F8TEL4
Pockets: 7 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Genome polyprotein	protein	590	25% helix, 23% strand	F8TEL4
A	Genome polyprotein	protein	40	0% helix, 30% strand	F8TEL4

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1125	0.81	0.82	85	empty
2	561	0.66	0.77	58	empty
3	105	0.43	0.78	19	empty
4	123	0.41	0.76	24	empty
5	78	0.41	0.79	20	empty

Interfaces

1 interface between chains.

B–A · 1792 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

5YVV · Crystal structure of full length NS3 protein (gD4NS2BNS3) from DENV4 in closed… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F8TEL4
Elsewhere: RCSB PDB 5YVV · PDBe 5YVV · UniProt F8TEL4

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