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Crystal structure of full length NS3 protein (GD4NS2BNS3) from DENV4 in closed conformation

Analyse Crystal structure of full length NS3 protein (GD4NS2BNS3) from DENV4 in closed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5YVV
Type: protein
Length: 630 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: F8TEL4
Pockets: 7 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Genome polyprotein	protein	590	25% helix, 23% strand	F8TEL4
A	Genome polyprotein	protein	40	0% helix, 30% strand	F8TEL4

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1125	0.81	0.82	85	empty
2	561	0.66	0.77	58	empty
3	105	0.43	0.78	19	empty
4	123	0.41	0.76	24	empty
5	78	0.41	0.79	20	empty

Interfaces

1 interface between chains.

B–A · 1792 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

5YVV · Crystal structure of full length NS3 protein (gD4NS2BNS3) from DENV4 in closed… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F8TEL4
Elsewhere: RCSB PDB 5YVV · PDBe 5YVV · UniProt F8TEL4

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