MolNFT v1 · #14077 · protein
Solution structure of alpha-cobratoxin complexed with a cognate peptide (minimized average structure)
1LXH · Long neurotoxin 1: “Solution structure of alpha-cobratoxin complexed with a cognate peptide (minimized average structure)”. Solution nmr, 1 pocket (best druggability 0.43). MolNFT v1 #14077 on GenesisL1: 3D structure, binding sites…
- PDB
- 1LXH
- Type
- protein
- Length
- 89 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Long neurotoxin 1; Acetylcholine receptor protein, alpha chain
- UniProt
- P01391, P02710
- Pockets
- 1 · best druggability 0.43
Structure
solution nmr · 2 distinct chains · 0% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Long neurotoxin 1 | protein | 71 | 0% helix, 21% strand | P01391 |
| B | Acetylcholine receptor protein, alpha chain | protein | 18 | 0% helix, 0% strand | P02710 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.43 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 639 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1LXH · Solution structure of alpha-cobratoxin complexed with a cognate peptide (minimized… · the same entry in another collection · chain A against A, TM-score 1.00
- P01391 · AlphaFold monomer V2.0 prediction for alpha-cobratoxin (P01391) · a predicted model of the same protein · chain A against A, TM-score 0.48
- P02710 · AlphaFold monomer V2.0 prediction for acetylcholine receptor subunit alpha (P02710) · a predicted model of the same protein · chain B against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01391
- Every structure of UniProt P02710
- Elsewhere: RCSB PDB 1LXH · PDBe 1LXH · UniProt P01391 · UniProt P02710
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