MolNFT v1 · #140741 · protein

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and atpgammas (CLASS2 at 4.57A)

5YKG: “Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and atpgammas (CLASS2 at…”. Electron microscopy, 2 ligands (AGS, GBM). MolNFT v1 #140741 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5YKG
Type: protein
Length: 6,536 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q61743, A0A1U7R319
Ligands: AGS, GBM

Structure

electron microscopy · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G	—	protein	325	—	Q61743
B, D, F, H	—	protein	1309	—	A0A1U7R319

Ligands and binding sites

AGS · Phosphothiophosphoric acid-adenylate ester · ligand · 8 copies · chains A, G, B, C, D, E, F, H
GBM · 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl) sulfamoyl]phenyl}ethyl)-2-methoxybenzamide · ligand · 4 copies · chains B, D, F, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5YKG · Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and… · the same entry in another collection · chain H against H, TM-score 1.00
Q61743 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q61743
Every structure of UniProt A0A1U7R319
Elsewhere: RCSB PDB 5YKG · PDBe 5YKG · UniProt Q61743 · UniProt A0A1U7R319

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