MolNFT v1 · #140613 · protein
Arga complexed with acecoa and glutamate
5YGE · Amino-acid acetyltransferase: “Arga complexed with acecoa and glutamate”. X-ray diffraction, 3 ligands (CAD, ACO, GLU), 3 pockets (best druggability 0.72). MolNFT v1 #140613 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5YGE
- Type
- protein
- Length
- 336 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amino-acid acetyltransferase
- EC
- 2.3.1.1
- UniProt
- O33289
- Ligands
- CAD, ACO, GLU
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amino-acid acetyltransferase (EC 2.3.1.1) | protein | 169 | 38% helix, 26% strand | O33289 |
| B | Amino-acid acetyltransferase (EC 2.3.1.1) | protein | 167 | 40% helix, 28% strand | O33289 |
Ligands and binding sites
- CAD · Cacodylic acid · ligand · 4 copies · chains A, B
- ACO · Acetyl coenzyme *A · ligand · 2 copies · chains A, B
- GLU · Glutamic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 640 | 0.72 | 0.79 | 74 | ACO, GLU, CAD |
| 2 | 276 | 0.66 | 0.82 | 33 | ACO |
| 3 | 55 | 0.38 | 0.80 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1170 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O33289
- Elsewhere: RCSB PDB 5YGE · PDBe 5YGE · UniProt O33289
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.