MolNFT v1 · #14057 · protein
Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 a resolution
1LWN: “Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at…”. X-ray diffraction, 2 ligands (PLP, GLC), 15 pockets (best druggability 0.85). MolNFT v1 #14057 on GenesisL1: 3D…
- PDB
- 1LWN
- Type
- protein
- Length
- 815 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen phosphorylase
- EC
- 2.4.1.1
- UniProt
- P00489
- Ligands
- PLP, GLC
- Pockets
- 15 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycogen phosphorylase (EC 2.4.1.1) | protein | 815 | 53% helix, 15% strand | P00489 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.85 | 0.95 | 47 | GLC, PLP |
| 2 | 146 | 0.79 | 0.96 | 40 | empty |
| 3 | 509 | 0.67 | 0.78 | 73 | empty |
| 4 | 179 | 0.55 | 0.79 | 25 | empty |
| 5 | 218 | 0.54 | 0.78 | 29 | empty |
Modifications
Observed in the structure: 1 cofactor, 1 modified (pyridoxal phosphate Schiff base, phosphorylation).
Compared structures
- 1LWN · Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00489
- Elsewhere: RCSB PDB 1LWN · PDBe 1LWN · UniProt P00489
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.