MolNFT v1 · #140542 · protein
Structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 2
5YE1 · Mucolipin-1: “Structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 2”. Electron microscopy, 17 pockets (best druggability 0.62). MolNFT v1 #140542 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5YE1
- Type
- protein
- Length
- 1,696 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mucolipin-1
- UniProt
- Q99J21
- Pockets
- 17 · best druggability 0.62
Structure
electron microscopy · 1 distinct chain · 54% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Mucolipin-1 | protein | 424 | 54% helix, 13% strand | Q99J21 |
Pockets
17 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 761 | 0.62 | 0.73 | 111 | empty |
| 2 | 655 | 0.59 | 0.72 | 92 | empty |
| 3 | 529 | 0.57 | 0.73 | 77 | empty |
| 4 | 424 | 0.53 | 0.73 | 76 | empty |
| 5 | 302 | 0.47 | 0.73 | 51 | empty |
Interfaces
6 interfaces between chains.
- B–C · 524 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 520 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 519 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 517 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 17 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99J21
- Elsewhere: RCSB PDB 5YE1 · PDBe 5YE1 · UniProt Q99J21
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