MolNFT v1 · #140042 · protein
Crystal structure of lyn kinase domain in complex with N-(1H-indazol- 6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine
5XY1 · Tyrosine-protein kinase lyn: “Crystal structure of lyn kinase domain in complex with N-(1H-indazol…”. X-ray diffraction, 1 ligand (8H0), 1 pocket (best druggability 0.66). MolNFT v1 #140042 on GenesisL1: 3D structure, binding sites…
- PDB
- 5XY1
- Type
- protein
- Length
- 253 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase lyn
- EC
- 2.7.10.2
- UniProt
- P07948
- Ligands
- 8H0
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase lyn (EC 2.7.10.2) | protein | 253 | 43% helix, 19% strand | P07948 |
Ligands and binding sites
- 8H0 · N-(1H-indazol-6-yl)-8-piperidin-4-yloxy-6-propyl-quinazolin-2-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 414 | 0.66 | 0.79 | 41 | 8H0 |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07948
- Elsewhere: RCSB PDB 5XY1 · PDBe 5XY1 · UniProt P07948
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