MolNFT v1 · #140041 · protein
Crystal structure of a serine protease from streptococcus species
5XXZ · Chemokine protease C: “Crystal structure of a serine protease from streptococcus species”. X-ray diffraction, 2 ligands (CA, SO4), 20 pockets (best druggability 0.75). MolNFT v1 #140041 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5XXZ
- Type
- protein
- Length
- 2,644 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chemokine protease C
- UniProt
- Q3HV58
- Ligands
- CA, SO4
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chemokine protease C | protein | 1334 | 11% helix, 34% strand | Q3HV58 |
| B | Chemokine protease C | protein | 1310 | 11% helix, 34% strand | Q3HV58 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 665 | 0.75 | 0.81 | 66 | empty |
| 2 | 607 | 0.75 | 0.82 | 81 | empty |
| 3 | 1078 | 0.73 | 0.76 | 84 | empty |
| 4 | 345 | 0.71 | 0.83 | 40 | empty |
| 5 | 685 | 0.69 | 0.77 | 66 | empty |
Interfaces
1 interface between chains.
- A–B · 163 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 50 modified (engineered).
Compared structures
- 5XXZ · Crystal structure of a serine protease from Streptococcus species · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3HV58
- Elsewhere: RCSB PDB 5XXZ · PDBe 5XXZ · UniProt Q3HV58
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