MolNFT v1 · #13993 · protein
Crystal structure of the beta-CATENIN/ICAT complex
1LUJ · Catenin beta-1: “Crystal structure of the beta-CATENIN/ICAT complex”. X-ray diffraction, 1 pocket (best druggability 0.51). MolNFT v1 #13993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1LUJ
- Type
- protein
- Length
- 572 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catenin beta-1; Beta-catenin-interacting protein 1
- UniProt
- P35222, Q9JJN6
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Catenin beta-1 | protein | 501 | 74% helix, 0% strand | P35222 |
| B | Beta-catenin-interacting protein 1 | protein | 71 | 51% helix, 0% strand | Q9JJN6 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.51 | 0.78 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 1478 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 1LUJ · Crystal Structure of the Beta-catenin/ICAT Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9JJN6 · AlphaFold monomer V2.0 prediction for beta-catenin-interacting protein 1 (Q9JJN6) · a predicted model of the same protein · chain B against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35222
- Every structure of UniProt Q9JJN6
- Elsewhere: RCSB PDB 1LUJ · PDBe 1LUJ · UniProt P35222 · UniProt Q9JJN6
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