MolNFT v1 · #139815 · protein

Crystal structure of RABA1A (Q72K) in complex with GTP

5XR7 · RAS-related protein RABA1A: “Crystal structure of RABA1A (Q72K) in complex with GTP”. X-ray diffraction, 2 ligands (GTP, MG), 6 pockets (best druggability 0.59). MolNFT v1 #139815 on GenesisL1: 3D structure, binding sites and…

PDB: 5XR7
Type: protein
Length: 333 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS-related protein RABA1A
UniProt: P28185
Ligands: GTP, MG
Pockets: 6 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS-related protein RABA1A	protein	167	35% helix, 28% strand	P28185
B	RAS-related protein RABA1A	protein	166	34% helix, 27% strand	P28185

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	316	0.59	0.77	46	empty
2	145	0.49	0.78	28	empty
3	94	0.41	0.78	26	GTP, MG
4	86	0.38	0.77	23	GTP, MG
5	78	0.37	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 530 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5XR7 · Crystal structure of RabA1a (Q72K) in complex with GTP · the same entry in another collection · chain A against A, TM-score 1.00
P28185 · AlphaFold monomer V2.0 prediction for RAS-related protein RABA1A (P28185) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28185
Elsewhere: RCSB PDB 5XR7 · PDBe 5XR7 · UniProt P28185

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.