MolNFT v1 · #139783 · protein
Structural basis of kindlin-mediated integrin recognition and activation
5XQ0 · Fermitin family homolog 2,INTEGRIN beta-1: “Structural basis of kindlin-mediated integrin recognition and activation”. X-ray diffraction, 11 pockets (best druggability 0.79). MolNFT v1 #139783 on GenesisL1: 3D structure, binding…
- PDB
- 5XQ0
- Type
- protein
- Length
- 834 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fermitin family homolog 2,INTEGRIN beta-1
- UniProt
- Q8CIB5, P09055
- Pockets
- 11 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fermitin family homolog 2,INTEGRIN beta-1 | protein | 424 | 37% helix, 24% strand | Q8CIB5, P09055 |
| B | Fermitin family homolog 2,INTEGRIN beta-1 | protein | 410 | 38% helix, 22% strand | Q8CIB5, P09055 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 476 | 0.79 | 0.86 | 48 | GOL |
| 2 | 484 | 0.73 | 0.82 | 48 | empty |
| 3 | 81 | 0.56 | 0.86 | 20 | empty |
| 4 | 56 | 0.47 | 0.85 | 14 | empty |
| 5 | 85 | 0.41 | 0.78 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 2412 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 5XQ0 · Structural basis of kindlin-mediated integrin recognition and activation · the same entry in another collection · chain A against A, TM-score 1.00
- Q8CIB5 · AlphaFold monomer V2.0 prediction for fermitin family homolog 2 (Q8CIB5) · a predicted model of the same protein · chain B against A, TM-score 0.86
- P09055 · AlphaFold monomer V2.0 prediction for integrin beta-1 (P09055) · a predicted model of the same protein · chain A against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CIB5
- Every structure of UniProt P09055
- Elsewhere: RCSB PDB 5XQ0 · PDBe 5XQ0 · UniProt Q8CIB5 · UniProt P09055
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