MolNFT v1 · #139777 · protein
Crystal structure of MAD2L2/REV7 in complex with a camp fragment in a monoclinic crystal
5XPU · Mitotic spindle assembly checkpoint protein MAD2B: “Crystal structure of MAD2L2/REV7 in complex with a camp fragment in a monoclinic crystal”. X-ray diffraction, 1 pocket (best druggability 0.55). MolNFT v1 #139777 on GenesisL1: 3D…
- PDB
- 5XPU
- Type
- protein
- Length
- 192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitotic spindle assembly checkpoint protein MAD2B; Chromosome alignment-maintaining…
- UniProt
- Q9UI95, Q96JM3
- Pockets
- 1 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitotic spindle assembly checkpoint protein MAD2B | protein | 179 | 37% helix, 20% strand | Q9UI95 |
| B | Chromosome alignment-maintaining phosphoprotein 1 | protein | 13 | 0% helix, 23% strand | Q96JM3 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 283 | 0.55 | 0.75 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 935 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5XPU · Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI95 · AlphaFold monomer V2.0 prediction for mitotic spindle assembly checkpoint protein MAD2B… · a predicted model of the same protein · chain A against A, TM-score 0.83
- Q96JM3 · AlphaFold monomer V2.0 prediction for chromosome alignment- maintaining phosphoprotein 1… · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UI95
- Every structure of UniProt Q96JM3
- Elsewhere: RCSB PDB 5XPU · PDBe 5XPU · UniProt Q9UI95 · UniProt Q96JM3
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