MolNFT v1 · #139536 · protein
Solution structure for human HSP70 substrate binding domain L542Y mutant
5XIR · Heat shock 70 kda protein 1A: “Solution structure for human HSP70 substrate binding domain L542Y mutant”. Solution nmr, 2 pockets (best druggability 0.63). MolNFT v1 #139536 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5XIR
- Type
- protein
- Length
- 185 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A
- UniProt
- P0DMV8
- Pockets
- 2 · best druggability 0.63
Structure
solution nmr · 1 distinct chain · 18% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A | protein | 185 | 18% helix, 30% strand | P0DMV8 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.63 | 0.85 | 33 | empty |
| 2 | 65 | 0.34 | 0.77 | 15 | empty |
Compared structures
- 5XIR · Solution structure for human HSP70 substrate binding domain L542Y mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DMV8
- Elsewhere: RCSB PDB 5XIR · PDBe 5XIR · UniProt P0DMV8
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