MolNFT v1 · #139314 · protein
Crystal structure of the PKA-protein a fusion protein (end-to-end fusion)
5XBY · Camp-dependent protein kinase type II-alpha regulatory…: “Crystal structure of the PKA-protein a fusion protein (end-to-end fusion)”. X-ray diffraction, 3 pockets (best druggability 0.44). MolNFT v1 #139314 on GenesisL1: 3D…
- PDB
- 5XBY
- Type
- protein
- Length
- 313 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding…
- UniProt
- P13861, P38507
- Pockets
- 3 · best druggability 0.44
Structure
x-ray diffraction · 4 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a | protein | 38 | 76% helix, 0% strand | P13861, P38507 |
| B | Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a | protein | 93 | 78% helix, 0% strand | P13861, P38507 |
| C | Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a | protein | 90 | 76% helix, 0% strand | P13861, P38507 |
| D | Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a | protein | 92 | 80% helix, 0% strand | P13861, P38507 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.44 | 0.79 | 15 | empty |
| 2 | 88 | 0.43 | 0.79 | 19 | empty |
| 3 | 104 | 0.35 | 0.73 | 24 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1019 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 1010 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 268 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 258 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 146 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5XBY · Crystal structure of the PKA-Protein A fusion protein (end-to-end fusion) · the same entry in another collection · chain D against D, TM-score 1.00
- P13861 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13861
- Every structure of UniProt P38507
- Elsewhere: RCSB PDB 5XBY · PDBe 5XBY · UniProt P13861 · UniProt P38507
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.