MolNFT v1 · #139300 · protein

Crystal structure of human IMPORTIN4

5XBK · Importin-4: “Crystal structure of human IMPORTIN4”. X-ray diffraction, 10 pockets (best druggability 0.77). MolNFT v1 #139300 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5XBK
Type: protein
Length: 1,480 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin-4; Histone H3
UniProt: Q8TEX9
Pockets: 10 · best druggability 0.77

Structure

x-ray diffraction · 5 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	Importin-4	protein	369	73% helix, 0% strand	Q8TEX9
A	Importin-4	protein	366	76% helix, 0% strand	Q8TEX9
B	Importin-4	protein	373	74% helix, 0% strand	Q8TEX9
C	Importin-4	protein	368	74% helix, 0% strand	Q8TEX9
E	Histone H3	protein	4	0% helix, 0% strand	—

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1084	0.77	0.79	99	empty
2	292	0.57	0.77	31	empty
3	50	0.40	0.82	12	empty
4	88	0.40	0.77	21	empty
5	115	0.39	0.75	23	empty

Interfaces

6 interfaces between chains.

D–A · 925 Å² buried · 3 hydrogen bonds · protein-protein
D–B · 791 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 537 Å² buried · 4 hydrogen bonds · protein-protein
B–E · 326 Å² buried · 6 hydrogen bonds · protein-protein
D–C · 244 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5XBK · Crystal structure of human Importin4 · the same entry in another collection · chain E against E, TM-score 1.00
Q8TEX9 · AlphaFold monomer V2.0 prediction for importin-4 (Q8TEX9) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TEX9
Elsewhere: RCSB PDB 5XBK · PDBe 5XBK · UniProt Q8TEX9

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