Parallel homodimer structures of voltage-gated sodium channel BETA4 for cell-cell adhesion

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 63% strand (DSSP).

Ligands and binding sites

• PG4 · Tetraethylene glycol · additive · 3 copies · chains A, B
• P33 · 3,6,9,12,15,18-hexaoxaicosane-1,20-diol · additive · 2 copies · chains A, B
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 1278 Ų buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 5XAW · Parallel homodimer structures of voltage-gated sodium channel beta4 for cell-cell adhesion · the same entry in another collection · chain A against A, TM-score 1.00
• Q8IWT1 · AlphaFold monomer V2.0 prediction for sodium channel subunit beta-4 (Q8IWT1) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8IWT1
• Elsewhere: RCSB PDB 5XAW · PDBe 5XAW · UniProt Q8IWT1